Abstract: In order to solve the problems of operation and maintenance difficulty, artificial experience limitation and low level of intelligent operation and maintenance under the condition of urban rail transit network operation, this article researched and designed a multi-disciplinary comprehensive intelligent operation and maintenance platform integrating vehicles, public works, power supply, communication, signal and station facilities and equipment based on the Internet of Things, cloud platform, big data, intelligent diagnosis and other new generation information technology. From the perspective of business requirements and technology driven, the article designed and detailed system technology architecture, main function design and key technology application, and clarified the platform construction ideas, implemented the functions of real-time monitoring, asset management, fault maintenance and decision-making analysis, which has reference significance to improve the operation and maintenance management level and digital support ability.