Abstract: Train operation scheme is the basis for the preparation of the train operation diagram. The reasonable design of train stop station plan has a direct impact on the distribution of passenger flow in the section. Through the study of the current train operation scheme, combining with the passenger flow and other data, considering the improvement of the line capacity and the utilization efficiency of the train capacity, this paper carried out the collaborative optimization research of this line train and cross line train. Based on the data, the paper puts forward the hypothesis conditions and establishes the collaborative optimization model of this line and cross line high-speed train operation scheme, used linear weighting algorithm of multi-objective optimization to transform and solve the objective function. Taking Beijing Shanghai High-speed Railway as an example, the paper calibrated the parameters of the model, and obtained the coordinated optimization scheme of this line and cross line train operation.The validity and feasibility of the model are verified through the comparative analysis of the station service frequency and stop station times between the current scheme and the optimized scheme.