Abstract: Through analyzing the current application status of safety production management information system for domestic railway scientific research enterprises, combining with the safety production actuality of china railway scientific research enterprises, this article proposed the general framework of safety production management information system for domestic railway scientific research enterprises based on unified application platform model, unified business logic model and unified external application integration interface. The article made a comprehensive summary and analysis for the general framework, business framework, logical framework, and key technology. It was implemented the classification management, grading processing, information sharing and comprehensive application of three level business data at enterprise level, sub enterprise level and department level.