Abstract: This article introduced the current situation and existing problems of the safety earning warning protection for railway operating workers and vehicles, combined with the advantages of Beidou satellite navigation system, used Beidou satellite system high-precision positioning technology, GIS, ground-based augmentation system, mobile communication technology and other auxiliary technology, put forward the solution of safety earning warning system for railway operating workers and vehicles based on Beidou. This solution could effectively solve the existing security risks for railway operating workers and vehicles in the process of construction. According to the construction safety area of pre-planning on the map and the relationship of the position between railway operating workers and vehicles, the system could real-time dynamic monitor the position of railway operating workers and vehicles on the map. When the distance between railway operating workers and vehicles reached the set risk distance, or the vehicles went into the construction work safety area, the system sent the early warning signal automatically to the railway operating workers, reminded railway operating workers caution, so then prevented and reduced the occurrence of safety accidents, ensured the safety of railway operating workers.