Abstract: The intelligent railway brain platform(IRBP) is an important part of the intelligent railway system, provides the perception, interconnection, processing, learning, decision-making and other capabilities for each business system. This paper proposed the positioning and connotation of IRBP, analyzed the core requirements of IRBP based on Data-Informatiion-Knowledge-Wisdom(DIKW), designed an overall framework including data layer, information layer, knowledge layer and decision interface layer based on Cyber Physical System(CPS) theory, presented the overall function of IRBP which consisted of data center, analysis center and decision center, and introduced the application of the brain platform in Haolebaoji-Ji'an railway.