Abstract: To master the safety status of railway power supply equipment and conduct targeted safety management, the objectives of building the comprehensive safety analysis system of railway power supply equipment are clarified and its overall framework is proposed based on the requirements of safety management of railway power supply from China Railway Taiyuan Group Co. Ltd. Therefore, the investigation and data arrangement of relevant data sources from existing information systems was made. Furthermore, the main functions of the system are designed and its key technologies are studied, laying the foundation for the development of the system.