Abstract: As a key equipment in the field of railway train control, interval integrated monitoring system(QJK) is responsible for ensuring the safe and efficient operation of trains. In order to verify the QJK engineering data and ensure the correctness and reliability of the data, this article proposed a python-based QJK engineering data calibration method. According to the characteristics of the engineering data of QJK, the rules of compiling IO table and the types of names summarized, the article designed an automatic calibration tool. Python script language and Wing IDE 6.0 integrated development environment were used to develop automatic calibration tools. The tool can verify the CAD files of the IO table and the data configuration files of the maintenance terminal, accurately and effectively point out the lack, redundancy and inconsistency of the data. It has been applied to the testing links of many QJK projects. The application results show that the automatic calibration tool can provide a strong guarantee for the security and correctness of QJK data.