Abstract: From the perspective of business development, information system and technology application of railway transportation informatization, combined with cloud native technology, this paper put forward some transformation ideas for the optimization route of railway transportation informatization, such as containerization, micro service, network combing and so on. The paper gave the basis of business split and logic split for the transformation of micro service, analyzed the transformation strategy of business optimization technology and information supporting technology involved in railway transportation production informatization. The precipitation and application of cloud native technology would not only empower the center strategic capability of the railway transportation production information business system, but also enhance the rapid iteration and business sharing capability of the railway enterprise information application.