Abstract: This article studied the integrated supervision and management system for centralized safety operation and maintenance of railway information system platform to solve the outstanding problems of railway information system operation and maintenance, such as that operation and maintenance tools were scattered, application monitoring was dispersed and more, operation and maintenance knowledge management was not enough, and operation and maintenance assessment indicators were single. According to the overall construction idea and principle of the system,the article designed the technical framework, application framework, and 9 sub functions of the system in detail,studied on a number of key technologies in the design process. The system implemented the "three sets" requirement of information system platform operation and maintenance, which was of great significance for improving the operation and maintenance level of railway informatization.