Abstract: As the traditional relational database can not meet the requirement of the weak current integrated system which is developed by using configuration software for real-time. A design method of RTDB applied to the weak current integrated system of trame was put forward by using main memory database technology and object-oriented modular design method. By analyzing the actual data characteristics, the data model of the RTDB was built. The lock transaction concurrency control technology based on priority two-phase lock algorithm was used to solve the real-time transaction conflict problem in RTDB. By using object-oriented modular design method and dynamic link library technology, some interface functions of the RTDB were provided. Taking the power supervisory system of one of the subsystems of the weak current integrated system as an example, it is proved that the RTDB meets the real-time requirements and has been successfully applied to the tram weak current integrated system in Shenzhen Longhua Line tram project for the moment.