Abstract: The existing material management information system of railway non-traffic enterprise was not considered the system flexibility at the beginning of the design, so the system was difficult to change with the change of business. In order to improve the existing material management information system, this paper used the method of TOGAF in enterprise architecture (EA), and put forward its research framework, which could help to solve the shortage of the existing system. The paper also constructed a case model of material management information system for China Academy of Railway Science, planned and designed its business structure, data structure, application framework and technical framework, in order to improve the informatization level of material management for railway non-traffic enterprise and establish the railway flexible material management information based system.