Abstract: In order to promote the construction of an online labor union platform, solve the security management difficulties of medical mutual assistance and difficult subsidies for the trans-provincial and city enterprise employees, this article researched and developed a railway enterprise labor union employee security information system by using MiniUi, SSH framework, and based on Oracle 11g database. The system has been put into operation in the Labor Union of China Railway Shanghai Group Co. Ltd., which has implemented the docking of basic personnel information, medical expense reimbursement information and external system, established paperless business process from workshop, unit to Railway Group Co. Ltd., established post internal control and supervision link, improved work efficiency and accuracy of various subsidies, and provided functions of subsidies self-service inquiry for employees. It can provide reference for the construction of labor union information system of large enterprises trans-provinces and cities.