Abstract: Aiming at the security problems that need to be considered in the process of enterprise application software design and development, this paper constructed a set of application software development security system suitable for enterprise. This paper analyzed the common vulnerability protection technologies of enterprise application software, according to the application software development life cycle process, reorganized and supplemented the framework of enterprise application software development security system from theaspects of design security, coding security, and process management security. Considering the corresponding security requirements under the framework of the system, in order to facilitate the guidance of application software designers and code developers, and improve the security capability of application software, the paper proposed a security system of enterprise application software development including technical requirements. The construction of enterprise application software development security system can help to reduce the software defects, prevent enterprise application software security vulnerabilities from being exploited by hackers, so as to avoid the possible serious or even catastrophic consequences.