Abstract: In order to implement integrated and intelligent compilation of train operation diagrams under cluster operation mode and improve the level of railway freight transportation services, this paper designed an intelligent compilation system for train operation diagrams based on cluster operation mode, proposed the overall architecture of the system based on the requirements of intelligent compilation and adjustment of cluster operation diagrams, designed five functional modules including data management, group planning, train operation planning, station operation planning, and operation diagram drawing and adjustment. Based on key technologies such as cluster operation diagram compilation, data exchange, and information sharing, the paper implemented reasonable and efficient transportation of multiple combination cluster trains and unit trains, met the actual needs of railway operation enterprise, and provided technical means for the compilation of train operation diagrams under cluster operation mode.