Abstract: With the growth of railway logistics demand, customers have higher and higher requirements for railway logistics efficiency. As the core node of railway logistics system, freight stations bear huge logistics pressure. In order to optimize the logistics efficiency of freight stations more accurately and effectively, based on the analysis of the logistics process of freight stations, this paper proposed a multi-index optimization model of logistics efficiency of freight stations and related optimization indicators. The model was applied to the actual freight station, and the logistics efficiency optimization index of the station was obtained, and optimization suggestions were put forward accordingly. The application results show that the optimization method can reduce the blindness of logistics optimization of freight stations and provide reference for the optimization of logistics efficiency of freight stations.