Abstract: In view of the problems existing in the development of Automatic Train Protection (ATP), this paper presented a software modeling method of on-board ATP subsystem based on domain meta-model, analyzed the common characteristics and requirements of different train operation control systems in the railway signal field for on-board ATP subsystem, built its domain meta-model based on the meta-model theory, and proposed a software development method of on-board ATP subsystem based on the domain meta-model. This method supports software model reuse and can improve the development quality and efficiency of on-board ATP subsystem software.