Abstract: Railway safety is an important prerequisite for operation. Due to the wide span and complex driving environment of China's railway, when the stability of railway infrastructure changes, it will seriously affect the driving safety. This paper used Long Short-Term Memory(LSTM)model to model and predict the deformation monitoring data of railway infrastructure monitoring system based on Global Navigation Satellite System(GNSS), Achieved early warning of railway infrastructure disasters, and compared it with various traditional time series prediction models. The experimental results show that the LSTM model has better performance.