Abstract: Aiming at the problems of low efficiency and data accuracy depending on the technical level of designers in the process of compiling interlocking control data, this paper proposed an automatic generation method of railway computer-based interlocking control data. Based on the basic data of railway stations in text format as input, the paper defined various data models, formulated spatial adjacency and logical adjacency rules, established the topological relationship between data models, and constructed the topological model of railway station yard; used the route search algorithm based on the shortest Euclidean distance to obtain all routes in the station; and automatically outputed interlocking control data, used the above method to develop practical software to show the automatic generation process of interlocking control data. The results show that the proposed method can generate interlocking control data quickly and accurately, improve the automation and efficiency of compiling interlocking control data, and help to improve the universality and adaptability of railway computer-based interlocking control system.