Abstract: To ensure the efficient and orderly promotion of digital transformation in railway scientific research enterprises, it is necessary to design a digital overall architecture for railway research enterprises. This paper was based on the TOGAF (The Open Group Architecture Framework) theory, combined with the key business and digital capability requirements of railway scientific research enterprises, studied the digital overall architecture of railway scientific research enterprises. The digital overall architecture mainly includes five parts: business architecture, application architecture, data architecture, technical architecture, and security architecture. This architecture can help railway scientific research enterprises further clarify their decision-making system, operation mode, capability building, and business structure, thereby provide reference and theoretical basis for scientific promotion and smooth implementation of digital transformation of railway scientific research enterprises.