Abstract: This paper designed a whole process management information system of fixed assets accounting in railway enterprises based on the concept of full life cycle asset management to solve the problems such as unsound centralized management and control mechanism of railway enterprises for fixed asset accounting data, and weak business coordination and internal card control. The paper used computer network and information technology to implement the whole business process management of assets from new establishment to final disposal by means of optimizing business process and setting up data centralized management and control mechanism, based on railway geographic information platforms, implement the visual display and analysis of the asset deployment and the overhaul change, realize the multilevel network management of the management departments at all levels of the railway enterprise, and meet the needs of the refined management for the assets of the railway enterprise.