Abstract: Using Anylogic simulation software, this paper makes a research on optimizing the passenger flow of metro stations from the aspects of the fluency, timeliness and comfort of metro stations and evaluates the passenger flow organization plan in terms of average number of passengers in line, average length of stay and area density. Taking Cross Station at Lanzhou West Railway Station as an example, inbound and outbound passenger flow lines and passenger-train hybrid simulation models of trains entering and leaving the station are established, and the passenger flows in the halls and on the platforms of the station are studied and main problems in the passenger flow are analyzed. Some suggestions on optimization of passenger flow by means of equipment configuration and management measures are proposed to deal with the bottleneck problems.