Abstract: In order to support the high speed train operation safety and improve maintenance efficiency, reduce the maintenance cost, eliminate the information island for the maintenance service, a full life cycle oriented Maintenance, Repair and Overhaul (MRO) System was established for the high speed train. This article analyzed the main problems in maintenance of the high speed train, discussed the operational framework of MRO System and proposed the design and implementation plan, illustrated the configuration management, fault management, maintenance scheduling management, on-line monitoring and diagnosis technology. The MRO System was taken good effect for the high speed train.