Abstract: In order to improve the information security of High-speed Railway Nature Disaster and Foreign Invasion Monitor System, ensure operational stability of the System, the paper designed Information Security System, combined with specific models and data processing of the System. The design was focused on the physical security, network security, host security, application security and data security for the software of High-speed Railway Nature Disaster and Foreign Invasion Monitor System. The application results showed that the software security architecture and design solutions could improve software security without reducing the performance of the software, effectively improve information security of the System.