Abstract: Aiming at prominent problems existing in railway district stations, including increasingly severe transportation capacity bottlenecks, low informatization level of existing equipment, high labor intensity and heavy safety pressure arising from manual-dependent operations, this paper designed an integrated automation system for railway district stations. The paper analyzed the differences between district stations and marshalling stations, constructed a four-layer system architecture adapted to district stations on this basis, and adopted technologies comprising automatic operation control coordinated with safety protection as well as automatic collection and structured processing of operational data. These technologies resolved the coordination contradiction between automatic operation execution and train operation safety protection, together with the problems of tedious manual data entry and low data utilization efficiency. Practical applications verify that the system improves station management efficiency and the level of operation automation, strengthens operational safety protection and lowers the labor intensity of frontline workers. It provides valuable references for the engineering implementation of integrated automation systems at railway district stations.