Abstract: Currently, artificial intelligence technology is rapidly empowering various industries with rich application scenarios, becoming an important means of improving new quality productive forces. The increasing complexity of artificial intelligence algorithms, the continuous expansion of data scale and modality, and the continuous enhancement of computility resources provide important foundations for the development and application of large models. This paper provided a detailed analysis of the research and application status of large model technology at home and abroad, and proposed an intelligent high-speed railway large model technology application architecture that deeply integrated large model technology with high-speed railway related application scenarios. It took artificial intelligence infrastructure, railway artificial intelligence platform, and railway artificial intelligence large models as the foundation support for intelligent high-speed railway scenarios, constructed intelligent high-speed railway intelligent agents, and then deeply empowered the intelligent construction, ntelligent operation, ntelligent equipment, basic platform and other related application scenarios of intelligent high-speed railway through intelligent agents, ultimately formed a complete intelligent high-speed railway large model technology application architecture.