Abstract: In response to the characteristics of high passenger volume, high departure frequency, and high requirements for platform screen door safety protection on suburban railway platforms, this paper analyzed a risk scenario where trains might depart abnormally when platform screen doors were not closed properly, used the EN50126 standard for safety analysis, and drew safety assessment conclusions, proposed specific safety protection measures, and utilized the onboard system, train control center system, and temporary speed limit server system to interact the platform screen door status and track circuit low-frequency code status, and comprehensively judged the departure logic to keep the train in a safe state when the platform screen door was in a fault state. Verification results show that the safety protection measures adopted have improved the safety and usability of the platform door system, ensure the safety of passengers during the transfer process, and provide reference for the adoption of similar standard suburban railway signal control systems.