Abstract: To cope with the deficiencies that the existing high-speed railway natural disaster and intrusion monitoring is limited by communication network conditions, this paper proposes a technical scheme of high-speed railway natural disaster and intrusion monitoring system based on 5G, which uses 5G communication technology to solve the transmission of large capacity monitoring data and real-time uploading of alarm information to monitoring terminals on running trains, which can effectively improve the high-speed railway's ability to deal with natural disasters, foreign object invasion and perimeter intrusion and other safety incidents, thus enhancing the train operation safety guarantee ability of high-speed railway.