Abstract: In view of the current situation and problems of commercial cryptography technology in railway application, combined with the application scenarios of industrial control system, cloud computing, Internet of Things and big data, this article studied the integration of railway commercial cryptography and new technologies, combined with the actual security requirements and cryptography application requirements of railway information system, put forward the security technology system of railway commercial cryptography. It lays the foundation for the more correct and effective application of commercial cryptography in railway industry.