Abstract: In order to improve the efficiency of integrated information processing and the ability of emergency command and dispatching in safety production command center of train operation stations and depots, on the basis of in-depth study on the daily business of safety production command of the stations and depots, the construction objectives and overall structure of safety production command assistant system were analyzed and proposed. Based on the key technologies of open source DWZ rich client (jQuery RIA framework), GIS technology, Web Service and Python background service application, the system implemented the collection, integration, cartographic display and convenient query of key information systems in train operation stations and depots. The test results show that the system can effectively enhance the emergency handling capacity of the stations and depots.