Abstract: With the promotion of high-speed railway construction and the increase of passenger flow, large passenger flow has become normal in many railway passenger stations. It is the key to ensure the safety of railway transportation to pay attention to the safety inspection of railway passenger transport under the condition of large passenger flow and develop of an information-based passenger safety inspection system. Based on the technical route of passenger service and production management and control platform, this paper put forward the railway passenger safety inspection system, and introduced details of main functions, system architecture, core modules, key technologies, application effect of the system. Through the pilot projects in Zhangjiakou Passenger Railway Station and Qingdao Passenger Railway Station, the functions of the system were tested. The results show that the recognition rate of contraband is higher than before. The application of the system implements the integration and sharing of security inspection information, which is conducive to find out the risks of railway stations operation safety, improves the work efficiency of security inspection, and ensures stable and efficient operation of station security inspection work.