Abstract: In view of the complexity of high-speed railway engineering structure, the systematicness of professional collaboration and the high reliability of operation safety, this paper studied the spatial-temporal information data organization model with all elements in whole domain for high-speed railway from the aspect of high-speed railway spatial-temporal information security. Taking the unique spatial-temporal benchmark as the main line, the paper associated different spatial-temporal information to form an efficient organization model of high-speed railway spatial-temporal information with all elements in the whole domain, so as to implement the effective organization of massive spatial-temporal information in various specialties and fields of high-speed railway; By using GIS (Geographic Information System) visualization technology, spatial analysis technology and big data real-time dynamic rendering technology, it was realized the real-time dynamic visualization display of different spatial-temporal information and organization relationship of high-speed railway, which provided auxiliary decision-making and spatial information technology support for independent prediction and early warning of high-speed railway operation safety situation.