Abstract: The wheel-rail interface of high-speed railway in China involves a wide range of subjects, usually includes mass experimental data and simulation data coming from different personnel in units, so deep analysis and comprehensive utilization to these data are very important to research the wheel-rail interface. Based on the B/S architecture, the high-speed railway wheel-rail interface comprehensive information system was developed. The system was with the functions such as data upload, checked, download, shared, etc., could manage the process of field test, simulation test and laboratory test, unify the track and vehicle data. It has important significance for the wheel-rail interface data standardization, unification and sharing. At present, this system is applied in many host plants, the feasibility and stability of the system function are verified.