Abstract: Electric Multiple Unit (EMU) routing scheduling is an important foundation of the EMU operation and maintenance plan, and it plays an important role in strengthening the operational management of EMU. This article focused on the problem of EMU routing scheduling, proposed a 0-1 mixed-integer programming model. The model was mainly taken the mileage and time cycle of EMU routine maintenance as the constraints, aimed at maximizing the running mileage and minimizing the total connection time of EMU. On this base, an example of optimizing the EMU routing scheduling was designed which was solved by the software of Lingo, and computed result verified the validity of the model.