Abstract: An optimal operation scheme of pick-up and drop train can effectively improve the level of car flow organization and utilization efficiency of equipment in the district. The operation scheme of pick-up and drop train is influenced by some factors such as the carrying capacity of the block section, the capacity of the station equipment, the distribution of the car flow, and so on. And it is also related to whether to operate the district train. According to the running characteristics of district train and pick-up and drop train, this paper analyzed the car-hour consumption and the influence of carrying capacity of the block section during trains running on the district, set up the optimization model by taking the minimization of accumulation car-hour and running car-hour of district train and pick-up and drop train, stopping car-hour and stop number of pick-up and drop train as the objective function. Finally, a numerical example was presented and the model was solved by using optimization software. The car flow organization scheme was acquired with the least total car-hour consumption, which proved the feasibility of the model.