Abstract: This article proposed and designed an intelligent strategy to select path in order to solve the blindness problems caused by setting routing algorithm manually in some multi-path software, implemented an intelligent algorithm to select path. The algorithm could automatically monitor the I/O data streams of every path between host and storage system by an independent thread, and then dynamically select an appropriate routing algorithm to select an optimized route. The algorithm was implemented on the Microsoft MPIO framework in multi-path environment. The test results showed that this algorithm ran with a better I/O transfer performance.