Aiming at the problems of low efficiency of manual inspection of railway signal machine room equipment, difficulty in ensuring the accuracy of equipment anomaly detection, low efficiency of fault handling, lack of technical support and safety control of on-site maintainers, this paper proposes a solution to the intelligent inspection system of railway signal equipment room, which is mainly composed of the intelligent inspection equipment in signal equipment room, the data center equipment and the maintenance terminal equipment. The intelligent inspection equipment adopts track-type inspection robot, which can automatically perform inspection operations according to the inspection plan, collect video/image and equipment temperature monitoring data and upload them to the data center equipment. The data center equipment adopts intelligent image analysis technology to automatically determine whether the equipment is abnormal. Once an anomaly is detected, the maintenance terminal equipment immediately alerts the dispatcher to ensure timely processing. On the basis of realizing the unmanned daily inspection work and achieving the goal of reducing personnel and increasing efficiency, with the help of the video monitoring and voice communication function of the robot, the system can also assist the signal maintenance personnel to carry out remote fault review and remote control of fault inspection, provide remote guidance for the on-site maintainers, verify the identity of the maintainers, and supervise their operation process, thus enhancing the safety control of on-site operations in signal equiment room.