Abstract: With the rapid development of railway informatization, equipment safety parameters and configurations have become increasingly complex. Therefore, it is urgent to strengthen the verification capability of networksafety configuration baselines. This paper studied the construction technology of safety configuration baseline knowledge base, multi-source asset configuration collection scheme, and proxy based configuration collection scheme, designed a railway information based equipment safety configuration verification system, and implemented visual management of equipment safety configuration baseline, configuration defect verification, risk analysis, and risk prevention. The results of pilot operation in multiple railway administration group companies show that the system can timely grasp the defects and risk situation of equipment safety configuration baseline, improve the safety protection capability of railway information based equipment.