Abstract: In order to improve the settle account operation mode of railway loading and unloading, improve the efficiency and accuracy of settle account operation of loading and unloading, this paper designed a settle account information system for railway loading and unloading based on the loading and unloading operation data of the railway freight production operation and control platform. The paper elaborated on its overall architecture and workflow, implemented functions such as loading and unloading work sheet/operation sheet management, workload statistics and analysis, settle account statistics and analysis, and loading and unloading parameter maintenance, optimized the organizational mode of loading and unloading operations. The system has been put into trial operation in China Railway Jinan Group Co. Ltd., and China Railway Zhengzhou Group Co. Ltd. It has obvious advantages in improving loading and unloading efficiency, ensuring safety production, improving loading and unloading statistical accuracy and traceability, and has significant effectiveness and promotion value.