Abstract: With the digital transformation of railway enterprises, the informationization construction of railway enterprises has fully entered the era of cloud computing, presenting a development pattern of multi cloud, hybrid cloud, and multi data centers. It is urgent to research and develop a unified management platform for multi centers and multi clouds geographically dispersed in multi locations to meet the needs of unified resource management and unified operation and maintenance across data centers. The article systematically analyzes the network security risks in a environment of multi centers and multi clouds geographically dispersed in multi-locations from the aspects of security attack and defense and security management. Combining the cloud security protection ideas of Gartner's cloud native security pyramid and MITRE cloud attack matrix, it proposes the construction ideas, protection schemes, and deployment modes of a multi location, multi center, and multi cloud security protection system to guide the cyber security construction of the management platform.