Abstract: In order to improve the security of data transmission in railway information systems, this paper studied the application scheme of railway office information system based on quantum communication. Based on quantum communication technology, this scheme encrypted and transmited sensitive information in the office information system, unified key management through the quantum key management server, provided key services for the railway office information system, implemented secure use of quantum keys for mobile terminals accessing the system by using the quantum security service platform, improved the overall security of railway office information systems.