Abstract: In order to improve the construction level of the entire life cycle of bridges, this paper carried out digital application research based on Building Information Modeling (BIM) for the Yellow River grand bridge of Zhengzhou-Jinan high speed railway, determined BIM design and construction application standards from the design side, established an overall structure LOD350 precision BIM model, carried out applications such as design drawing and technical disclosure, undertook BIM models from the construction end to the design end, and carried out in-depth design and construction simulation applications. Based on BIM+Geographic Information System (GIS) technology, the paper implemented three-dimensional visualization of construction progress and safety quality management, provided information support for project implementation and management, deeply integrated information technology with construction site management to build a digital construction site and assist in the comprehensive upgrading of construction management methods. Through the application practice of the Zhengzhou-Jinan high-speed railway BIM project, a full process digital technology route covering overall planning, standard formulation, BIM application and project comprehensive management has been formed, which can provide reference for the digital comprehensive application of similar civil engineering construction projects.