Abstract: In order to solve the problems of excessive personnel investment, untimely alarms, and inaccurate alarm information in the operation and maintenance of the customs information system (abbreviated as operation and maintenance), this paper proposed an intelligent operation and maintenance system for the core computer room information system. The paper applied the Configuration Management DataBase (CMDB) based on graph database to serve the entire process of intelligent operation and maintenance, used the out of band management and in band management technology to design patrol robots, studied the discrimination algorithm for intelligent analysis of massive operation and maintenance data, and implemented the full link monitoring, intelligent analysis, and accurate alarm functions for the customs information system. The application in the operation and maintenance of the SHANGHAI CUSTOMS DISTRICT supervision information system shows that the intelligent operation and maintenance system can effectively reduce human resource costs and information system failure rates, and continuously improve the effectiveness of system operation and maintenance.