Abstract: This paper introduced the intergenerational characteristics of information system development, researched on the development direction of next generation railway information system based on the cloud brain platform architecture mechanism and in combination with the railway information system's own reality and development goals, and proposed to carry out research work on cloud edge collaboration and ubiquitous interconnection, cognition oriented and intelligent processing in advance, so as to provide reference for promoting the high-quality development of railway information system and the process of railway digitalization, networking and intelligence.