Abstract: With the increasing traffic and data volume of railway information system, it is urgent to explore a new architecture to improve the autonomy and responsiveness of the system. Combining with the business characteristics of railway information system, this paper proposed a cloud-edge collaboration architecture suitable for railway information system, expounded in detail the technical system of cloud-edge collaboration and key technologies such as microservices, container orchestration and edge computing, and introduced its application scenarios in railway information systems. It can provided a reference for the implementation of cloud edge collaboration technology in the railway field.