Abstract: Based on the requirements of railway informatization, intelligent development and communication cloud deployment, this paper sorted out the business application deployment requirements of railway data center. By analyzing the layout of typical enterprise data centers and the architecture of national-wide integrated big data center, the paper put forward that the railway data center could adopt the secondary architecture planning of CHINA RAILWAY level and railway administration group company level, and the layout of railway primary data center could dynamically evolve from active standby mode to distributed multi active mode. According to the site selection factors, the paper divided the whole country into regions, and put forward the proposed location areas of railway data center in different evolution processes. The planning of railway data center supports the construction of intelligent railway, and the combination with the national-wide integrated big data center helps to promote the development of the whole intelligent transportation industry.