Abstract: To ensure the quality of railway 12306 Internet ticketing and reservation system (hereinafter referred to as 12306), it is necessary to adopt necessary testing methods and technologies. This paper analyzed the testing methods in each stage of software testing, and introduced application methods of four key technologies in the 12306 testing : automatic testing, test simulator, cloud testing and mobile App compatibility testing. The practice proves that the use of reasonable and effective testing technologies is very important to ensure the smooth operation of 12306.