Abstract: With the rise of the concept "wisdom stations", currently the stations and deports across China Railway are vigorously promoting enterprise informatization, building information systems to meet the needs of production and office aotomation. Generally, information interconnection in production, management, training and other aspects has been realized and those information systems has gradually become key facilities to support the production of stations and deports. Once encountering security threats, the normal production order of railway stations and deports would be disturbed directly and even affect railway transport production. Therefore, with reference to the basic requirements of classified cyber security protection of information technology and in combination with practices of the construction and application in the locomotive servicing operation comprehensive management information system in a locomotive depot, relatively perfect security management measures have been established according to the characteristics and requirements of security management of railway station and deport information system from the perspectives of comprehensive prevention and control over personals, materials, technologies, thus effectively ensuring the long-term stable operation of the system. Finally, thinking and suggestions on security management of railway station and deport information system are given.