Abstract: In view of the complexity of regional division in railway integrated information network and the diversification of boundary security protection strategies, starting from the current situation of regional division of railway integrated information network and the characteristics of cross regional communication, and according to the protection requirements of network security level protection 2.0 series standards for regional boundaries, this paper put forward five typical regional boundary types in railway information network. Combined with the mainstream boundary safety protection technology in the industry, it provided corresponding safety protection measures and suggestions for different types of regional boundaries. The proposed typical regional boundary types and protection measures would provide a template reference for the daily operation and maintenance of railway comprehensive information network and provide some ideas for the construction of safety protection system.