Abstract: The domestication reformation of the railway information systems is the only way to ensure the safe operation of Chinese railways, protect the data privacy of the railway systems, and avoid getting stuck. At present, railway information systems have become indispensable technical support to guarantee the normal operation of railway. And the domestication reformation of existing railway information systems is a difficult task and it is urgent to clarify the goals and strategies of domestication reformation and to study the transformation scheme in a systematic approach. Therefore, this article analyzes the background, present situation and existing problems of localizing railway information systems and put forward the strategies of localization work, implementation process and promoting suggestion in hope of pushing the localization of railway key information systems, enable the core technologies adopted by those systems to be completely autonomous and controllable, eliminate the potential risk and safety concerns as early as possible so as to guarantee the long-term safe and stable operation of railway information systems.